Babban dalilin ciwon zuciya , bugun jini da sauran raunin jini shine atherosclerosis. Babban halayen ci gaba da ilimin cututtuka ne cholesterol (lipophilic barasa) ke bugawa, wanda kwayoyinsa an ajiye su a kan ganuwar arteries da capillaries a cikin nau'i mai yawa. Dole ne a rage girmanta don yin rigakafi da magani na atherosclerosis.
Statins - mece ce?
Yawancin mutanen da ke fama da cututtuka na zuciya da jijiyoyin jini sun gane magungunan da aka kwatanta da lipid a matsayin magunguna mafi inganci da lafiya wanda ya rage cholesterol. Wannan ba gaskiya ba ne. Don fahimtar abin da ya shafi asali, yana da muhimmanci a san hanyar da aka samu da kuma rarrabawar barasa lipophilic, da manufarsa da aiki.
Za a iya samar da cholesterol a cikin jiki, kuma shigar da shi daga waje, misali, tare da abinci. Wannan ƙungiyar shirya wajibi ne don:
- biosynthesis na corticosteroids da jima'i hormones;
- kariya na erythrocytes daga hemolytic poisons;
- tsari na cell permeability;
- samar da bile acid da bitamin na rukuni D;
- gyare-gyaren membrane na plasma.
Jigon jikin mutum yana haifar da sunadaran gina jiki - lipoproteins. Suna taka muhimmiyar rawa na masu dauke da kwayoyin cholesterol daga hanta zuwa kyallen takarda da baya. Statins sun hana samar da enzymes wanda ya riga ya samo lipoproteins. Saboda haka, adadin cholesterol ya shiga raguwa da takarda, kuma ƙarawar karuwa ya karu. A sakamakon haka, yawan kwayar lipophilic da ke cikin jiki yana ragewa sosai. Bugu da kari, kwayoyi da aka yi la'akari suna taimakawa wajen kare kariya daga kyakkun kwayoyi masu tasowa da kwanciyoyi a cikin tasoshin.
Statins daga cholesterol suna da kyau kuma mummunan
Ko da magungunan ƙwayoyin lipid din da suka fi tasiri suna da mummunar tasiri, saboda haka an hana su sosai don zaɓar su dauki kansu. Ana ba da ka'idojin dokoki ne kawai idan akwai shaidun shaida na amfani da su. A mafi yawancin lokuta, za a iya rage ƙwayar cholesterol a wasu hanyoyi masu aminci da lafiya. Wadannan sun hada da gyaran abinci, da ƙin yarda da miyagun ƙwayoyi, da karuwa a matakin aikin jiki da kuma daidaita ka'idojin aiki da hutawa.
Statins daga cholesterol suna da kyau
Kwayoyin da aka bayyana sun kasance kawai zaɓi don yin rigakafi da maganin cututtuka na kwayar cutar na zuciya mafi haɗari, lokacin da hanyoyin miyagun ƙwayoyi ba su iya isa ba. Amfanin statins sune wadannan:
- rage yawan hadarin zuciya;
- yin rigakafi na hare-haren ƙwaƙwalwa , bugun jini;
- jinkirin ci gaba da hana ci gaban atherosclerosis;
- Kaddamar da aikin zuciya akan angina, cututtukan ischemic;
- taimako na bayyanar cututtuka na ciwon sukari mellitus;
- asarar nauyi da kiba.
- raunana matakai na ƙananan ƙwayoyin cuta a kan gandun daji;
- Daidaitawa na alamar atherosclerotic ;
- zubar jini, wanda ya rage hadarin jini;
- daidaituwa na tsarin tafiyar rayuwa cikin jiki;
- vasodilation.
Statins daga cholesterol sune mafi amfani da kwayoyi masu guba don tabbatar da sake gyarawa bayan:
- tsinkaye;
- hadaddun cututtuka;
- gyare-gyare na jijiyoyin zuciya na tiyata;
- angioplasty;
- ƙananan ƙananan haɗari;
- amintattun abubuwa.
Cutar launi
Babban haɗari na yin amfani da waɗannan magunguna shine haɗarin tasiri. A cikin layi daya tare da ragewa a samar da lipoproteins, maganin kwayoyi sun rage yawan samar da coenzymes Q10. Wadannan maharan sunadarai suna samar da makamashi ga tsokoki na jiki da kwakwalwa. Tare da rashi na coenzymes, ana ganin wadannan matsalolin:
- gajiya;
- rauni da zafi a cikin tsokoki;
- haɓakawa da kaifi suna tsallewa cikin karfin jini;
- ƙwaƙwalwar zuciya ta rikici;
- halakar tsoka nama (rhabdomyolysis).
Akwai wasu abubuwa masu ban sha'awa da suka faru da cututtukan kwayoyin - sune:
- rashin barci;
- lalacewa na ji da kaifi na dandano dandano;
- rage yawan plalet count a cikin jini;
- ƙwannafi;
- zubar da jini na yau da kullum;
- zafi a yankin yankin;
- ƙara yawan mita urination;
- rikici;
- ƙara karuwa;
- cin zarafi;
- rashin lafiyan halayen;
- dizziness;
- Nausea;
- busassun tari;
- Tsarin rubutu;
- Ƙara ƙwallon ƙwallon ƙwaƙwalwa zuwa radiation ultraviolet;
- kwari;
- redness da itching na epidermis;
- flatulence;
- vomiting;
- ƙara yawan sauyawa na nakasa na asibiti;
- yanayin damuwa;
- rushewar kwakwalwa;
- saurin yanayi;
- jaundice;
- launi
- shakatawa;
- exacerbation na arthritis da arthrosis;
- saurin yanayi;
- irritability;
- raunuka na wadanda ba mai kumburi jijiya ba;
- anorexia;
- vomiting;
- peeling da peeling daga cikin fatar jiki na fata;
- hepatitis;
- haɓaka cikin matakan jini;
- shan kashi da kumburi da kodan.
Ko da magunguna masu lafiya suna da tasiri mai yawa, amma suna da wuya sosai kuma mafi yawa a cikin mutanen da ba su bi ka'idojin yin amfani da maganin ba. Yin jiyya tare da magungunan ƙwayoyi masu lakabi sun haɗa da kin amincewa da barasa, shan taba, motsa jiki na yau da kullum da kuma abincin abincin lafiya. Idan kun bi waɗannan ka'idoji, ana iya kaucewa sauƙi.
Yawancin statins
An cire abubuwa masu maƙalafan farko daga kayan samfurori. Bisa ga waɗannan mahadi, an ci gaba da yin amfani da kwayoyi na ƙungiyar lovastatin. Sauran bambance-bambancen da kuma sababbin ƙwayoyi masu amfani da kwayoyi anyi su ne daga kayan hade. Ba daidai ba ne a yi imani da cewa ka'idodi na halitta daga cholesterol su ne mafi tasiri da aminci. Magungunan ƙwayoyi masu yawa ba su da wata tasiri mai tasiri kuma an fi dacewa da su. Baya ga lovastatin, ƙwararrun ƙarni na waɗanda aka kwatanta sun hada da simvastatin da pravastatin.
Ko da magungunan lipid-lowering suna haifar da sakamako. Ana amfani dasu mafi kyau a cikin rigakafin cututtuka, atherosclerosis, infarction na sirri, musamman ma idan akwai tsinkaye akan abubuwan da aka lissafa. Bayani ga shan magungunan farko:
- coronary atherosclerosis;
- Daidaitawar cin abinci a cikin hadaddun da kayan jiki;
- primary hypercholesterolemia.
Rashin ƙarni na biyu na magungunan da aka yi amfani da su shine wakilci kawai ne kawai. Wadannan kwayoyi ne masu inganci da lafiya wanda za'a iya tsara har ma yara daga shekaru 10. Sun ƙunshi gishiri na sodium, saboda haka yawancin ƙwayar cholesterol a cikin jini an rage shi da sauri. Hanyar da ake amfani dashi don amfani da fluvastatin:
- dyslipidemia na mixed irin;
- cututtukan cututtukan zuciya (don hana rikitarwa);
- coronary atherosclerosis;
- hypercholesterolemia;
- Rigakafin cututtuka na zuciya da kuma tiyata.
Sakamakon ƙarni na uku na magungunan ƙwayoyin lipid-downering shine atorvastatin. Mahimmancin wadannan kwayoyi sune ingantacciyar cigaba a cikin aikin tsarin kwakwalwa cikin jiki. An yi imani da cewa statins daga cholesterol su ne mafi sauri, mafi inganci da lafiya dukunan don rigakafin ciwon sukari da kuma cututtuka na zuciya da jijiyoyin jini, ciki har da cutar mai yawan gaske. Bayarwa ga manufar su:
- asarar rigakafi ga cututtuka na tsarin jijiyoyin jini;
- mixed dyslipidemia;
- auna hypercholesterolemia;
- m atherosclerosis.
Ƙididdigar sababbin ƙarni sun haɗa da Petervastatin da rosuvastatin. Wadannan kwayoyi sune sababbin abubuwan da suka faru a fannin ilmin likitanci, suna da dama da dama akan wadanda suka riga su:
- sakamako mai saurin gaske (sakamako ne mai sanarwa daga farkon mako na shiga);
- ƙananan maganin warkewa;
- ci gaba da aiki;
- ƙananan haɗarin tasiri;
- da yiwuwar yin amfani da lokaci tare da jami'in zuciya;
- babu wani tasiri akan metabolism na glucose.
Sabbin ka'idodin daga cholesterol sune mafi mahimmanci da lafiyar magunguna da aka ba da shawara a cikin wadannan lokuta:
- hypercholesterolemia a kowane mataki;
- ci gaba, rikitarwa atherosclerosis;
- cututtukan cututtukan zuciya ne;
- ciwon sukari mellitus ;
- dyslipidemia;
- jigilar kwayoyin halitta ta hanyar rigakafi;
- gyaran zuciya bayan ciwon zuciya, bugun jini, tiyata.
Magunguna na Statin - lissafin
Magungunan da ke sama a kowani tsara suna da sunayen daban-daban na kasuwanci. Yi amfani da kwayoyi wanda ya rage cholesterol cikin jini, ba za ka iya ba. Abinda yake aiki mara dacewa, sashi ba daidai ba, hade tare da wasu rukunonin pharmacological jamiái na iya haifar da haɗari da cututtuka masu illa mafi haɗari da canje-canje marar iyaka a cikin aikin hanta, tafiyar matakai. Sai dai likita mai likita ya kamata ya ba da shawarar abin da kwayoyi ya rage cholesterol a cikin jini lafiya da yadda ya kamata. Ƙwararrun fitattun statins an zaɓa ta hanyar gwani.
Simfastatin analogues
Ana sayar da wannan abu a cikin nau'i na allunan guda. A matsayin mai aiki mai aiki, simvastatin yana dauke da kwayoyi marasa ladabi masu zuwa - jerin:
- Simvastol;
- Zobatin;
- Simgal;
- Zocor;
- Simvagexal;
- Soest;
- Simvard;
- Vastatin;
- Simvakor;
- Ovenkor;
- Simlo;
- Vazilip;
- Sincard da sauransu.
Analogues na al'ada
Wannan wani wakili ne mai inganci da mai aminci na ƙarnin farko na kwayoyi masu lalata. Mafarki mai aiki wanda aka bayyana ya ƙunshi irin kwayoyi da rage cholesterol cikin jini (statins):
- Alamar shiga;
- Lipostat;
- Sabuntawa.
Analogues na lovastatin
Maganin ƙwayar cutar ta farko, wanda ya ware daga fungi na penicillin, ba shine mafi tasiri ba, amma daya daga cikin mafi aminci. Drugs cewa rage cholesterol, bisa ga lovastatin:
- Holletar;
- Lovacor;
- Cardiostatin;
- Lovasterol;
- Mevakor;
- Lovastatin;
- Apexstatin;
- Lovahexal;
- Madauki;
- Rovacor;
- Liprox da sauransu.
Analogues kamar yadda ya kamata
Statins daga ƙwayoyin cholesterol na biyu suna wakiltar abu daya kawai. A bisa tushensa kawai ana samar da Allunan - Leskol. An sayar da su a cikin nau'i uku da iri guda (80 MG):
- Na gargajiya (Leskol);
- Ƙara;
- XL.
Atorvastatin - analogues
Wannan nau'in haɓaka na hypolipidem ya kasance na uku na magunguna. Shirye-shirye na statin a kan tushensa:
- Lipitor;
- Anistat;
- Liprimar;
- Atorvastatin;
- Tulip;
- Atomax;
- Canon;
- Taswira;
- Atorvox;
- Liptonorm;
- Atoris da sauransu.
Ana amfani da analogues na Rosuvastatin
Statins don rage yawan cholesterol daga ƙarni na huɗu sun fi dacewa da aminci yana nufin tare da aiki mai tsawo. Rosuvastatin, baya ga Allunan irin wannan sunan, yana cikin wadannan maganin:
- Mertenil;
- Rosulip;
- Cross;
- Rosewood;
- Akorta;
- Rosart;
- Tevastor;
- Roxer.
Analogues na Bitrusvastatin
An yi amfani da kwayoyi masu ragu na lipid na ƙarni na hudu tare da miyagun ƙwayoyi a cikin tambaya kawai 'yan shekaru da suka wuce. Wadannan abubuwa daga cholesterol sun fi dacewa da lafiya daga dukkan magungunan magungunan. Suna da sauri da kuma mafi tsawo tasiri ba tare da wani hadarin kiwon lafiya. Bisa ga Bitrusvastatin, zaɓi ɗaya kawai yana samuwa - Livazo.
Statins na sabon ƙarni tare da ƙananan sakamako
Masanan likitoci sun fi so su rubuta kwayoyi marasa lafiya kawai da magungunan magani marasa mahimmanci da kuma aiki mai tsawo. Tasirin da ya fi tasiri daga cholesterol shine rosuvastatin da Petervastatin:
- Cross;
- Mertenil;
- Roxer;
- Valarox;
- Rosáv;
- Akorta;
- Rosewood;
- Livazo.